Amy M. Boddy
University of California, Santa Barbara
Students Kenna & Sydney are volunteers at the Santa Barbara zoo this summer!!!
My research focuses broadly on evolutionary applications to human health and disease. My work is motivated by fundamental questions in life history theory. I use a combination of genomics, computational biology and evolutionary theory to help understand trade-offs between survival and reproduction across different levels of biological organization, from molecules to organisms and everything in between.
An evolutionary perspective on maternal health and disease
Previous literature paints a paradoxical picture on fetal cell’s influence on the maternal body. Our recent review on fetal microchimerism and maternal health/disease proposes numerous predictions on why we see this paradoxical effect. Through an evolutionary lens, the ecological context (each mothers body) is important for determining whether fetal cells may contribute to maternal health or disease. Drawing from this theory, we can now design more informed hypothesis driven experiments to explicitly test functional, regulatory and genetic dynamics of maternal-fetal interactions.
Trade-offs between cellular proliferation and survival in cancer progression and treatment
Can organismal life history theory can be applied at the cellular level? Are there distinct cellular populations that invest in proliferation, at the expense of survival? I am using life history theory, agent-based modeling and genomic techniques to 1) help understand why we see this diversity of phenotypes in cancer, 2) provide a new perspective in treatment design and 3) understand the molecular processes underpinning cellular trade-offs.
Trade-offs in Cancer Defense
Exploring the diversity in cancer susceptibility
Cancer suppression is a major component of somatic maintenance, including DNA repair, cell cycle control and immune function. There is likely trade-offs between growth, reproduction and cancer defenses. My research aims to 1) understand the trade-offs between reproduction and cancer defenses and 2) uncover the molecular drivers facilitating this diversity in cancer susceptibility.
Molecular Evolution and Transcriptomics
Using comparative genomics to examine patterns of parallel evolution
Brain expansion is a key characteristic of primate and human evolution. Uncovering the molecular basis of human brain evolution may identify ways in which our own species is unique. Whether adaptations governing brain expansion are shared across primates or have a species-specific origin is unclear. To provide insight into pathways and processes important in brain size evolution, we are analyzing patterns of molecular evolution across independent episodes of brain size increase during anthropoid primate evolution.
We are currently recruiting postdoctoral researchers and graduate students. If interested, please email Dr. Boddy: boddy(at)anth.ucsb.edu
I am passionate about behavioral neuroscience and genetics. Specifically, I am interested in mental illness and using genomics to find cures for complex diseases such as cancer. I expect to graduate in June 2021.
I am interested in evolution and genetics. I am specifically interested in how we can use genetics and evolutionary theory to find cures for medical diseases. I expect to graduate in 2020.
A Aktipis, L Cronk, J Alcock, JD Ayers, C Baciu, D Balliet, AM Boddy, OS Curry, JA Krems JA, A Muñoz, D Sullivan.
Nature Human Behaviour. 2018 Jul;2(7):429.
CC Maley, A Aktipis, TA Graham, A Sottoriva, AM Boddy, M Janiszewska, AS Silva, M Gerlinger, Y Yuan, KJ Pienta, KS Anderson, R Gatenby, C Swanton, D Posada, C Wu, JD Schiffman, ES Hwang, K Polyak, ARA Anderson, JS Brown, M Greaves, D Shibata
Nature Reviews Cancer. 2017
M Tollis, AM Boddy, CC Maley
BMC biology 15 (1), 60. 2017
AM Boddy*, PW Harrison*, SH Montgomery*, JA Caravas, MA Raghanti, KA Phillips, NI Mundy, DE Wildman
Genome biology and evolution 9 (3). 2017 | * contributed equally
M Tollis, JD Schiffman, AM Boddy
Current Opinion in Genetics & Development 42, 40-47. 2017
VK Harris, JD Schiffman, AM Boddy
Ecology and Evolution of Cancer. Elsevier. 2017
A Fortunato, AM Boddy, D Mallo, A Aktipis, CC Maley, JW Pepper
Cold Spring Harbor Perspectives in Medicine 7 (2), a029652. 2017
SL Díaz‐Muñoz, AM Boddy, G Dantas, CM Waters, JL Bronstein
Evolution 70 (12), 2669-2677. 2016
D Chowell, AM Boddy, D Mallo, M Tollis, CC Maley
Genome biology 17 (1), 34. 2016
BH Hidaka, AM Boddy
Evolution, medicine, and public health (1), 17-20. 2016
AM Boddy, A Fortunato, M Wilson Sayres, A Aktipis
BioEssays 37 (10), 1106-1118. 2015
CA Aktipis, AM Boddy, G Jansen, U Hibner, ME Hochberg, CC Maley, GS Wilkinson
Phil. Trans. R. Soc. B 370 (1673), 20140219. 2015
AM Boddy, H Kokko, F Breden, GS Wilkinson, CA Aktipis
Phil. Trans. R. Soc. B 370 (1673), 20140220. 2015
CA Aktipis, AM Boddy, RA Gatenby, JS Brown, CC Maley
Nature Reviews. Cancer 13 (12), 883. 2013
KN Sterner, MR Mcgowen, HT Chugani, AL Tarca, CC Sherwood, PR Hof, CW Kuzawa, AM Boddy, RL Raaum, A Weckle, L Lipovich, LI Grossman, M Uddin, M Goodman, DE Wildman
American Journal of Human Biology 25 (3), 418-430. 2013
KN Sterner, A Weckle, HT Chugani, AL Tarca, CC Sherwood, PR Hof, CW Kuzawa, AM Boddy, A Abbas, RL Raaum, L Grégoire, L Lipovich, LI Grossman, M Uddin, M Goodman, DE Wildman
PloS one 7 (5), e37714. 2012
AM Boddy, MR McGowen, CC Sherwood, LI Grossman, M Goodman, DE Wildman
Journal of evolutionary biology 25 (5), 981-994. 2012
I Hinterseher, R Erdman, LA Donoso, TR Vrabec, CM Schworer, JH Lillvis, AM Boddy, K Derr, A Golden, WD Bowen, Z Gatalica, N Tapinos, JR Elmore, DP Franklin, JL Gray, RP Garvin, GS Gerhard, DJ Carey, G Tromp, H Kuivaniemi
Arteriosclerosis, thrombosis, and vascular biology 31 (7), 1653-1660. 2011
CC Sherwood, MA Raghanti, CD Stimpson, MA Spocter, M Uddin, AM Boddy, DE Wildman, CJ Bonar, AH Lewandowski, KA Phillips, JM Erwin, PR Hof
Proceedings of the Royal Society of London B: Biological Sciences 277. 1684. 2010
J Nischan, GM Lenk, AM Boddy, JH Lillvis, G Tromp, H Kuivaniemi
Aneurysms: Types, Risks, Formation and Treatment, Nova Science Publishers. 35-93. 2010
JR Elmore, MA Obmann, H Kuivaniemi, G Tromp, GS Gerhard, DP Franklin, AM Boddy, DJ Carey
Journal of Vascular Surgery 49 (6), 1525-1531. 2009
AM Boddy, GM Lenk, JH Lillvis, J Nischan, Y Kyo, H Kuivaniemi
Drug News Perspect 21 (3), 142-148. 2008
H Kuivaniemi, AM Boddy, JH Lillvis, J Nischan, GM Lenk, G Tromp
Aortic aneurysms, new insights into an old problem, 299-323. 2008
Cooperation & conflict in maternal health
ASU Cooperation & Conflict Symposium
See Dr. Boddy present work on microchimerism and maternal-fetal conflict
Amy M. Boddy
Assistant Professor in the Department of Anthropology at the University of California, Santa Barbara. She received her Ph.D. in Molecular Biology and Genetics from Wayne State University - School of Medicine in Detroit, Michigan.
ANTH 177AB Human Reproductive Ecology and Endocrinology
This course will discuss the regulation of reproductive function in humans by diet, energy balance, lactation, and social context. We will focus on the role of hormones in the regulation of human reproduction, behavior, and physiology. The curriculum will follow hormonal changes during the human life course, including puberty, menstruation, pregnancy, lactation, parenting and menopause.
Anth 9 Human Behavioral Sciences Methods Lab
The goal of this course is to introduce students to the design and analysis of scientific studies of behavior. The emphasis in the class is on theory-based testing of workable hypotheses, with examples drawn from human evolutionary ecology and human biology. Classes are structured around methods of data collection and analysis. Students are introduced to a range of quantitative and qualitative methods, from observational and survey-based studies of behavior to experiments. Classes are held in a computer laboratory, where students use database and statistical software to organize and analyze real data.
Anth 171 Evolutionary Medicine
This course is designed to introduce applications of evolutionary biology to medicine. Topics ranging from the evolution of antibiotic resistance, to aging, obesity, complications in pregnancy and cancer. These topics will be discussed using an evolutionary framework to better understand how these diseases/issues came to be, and what can be done to prevent/treat/mitigate these conditions.